Why must one walk up a rampfrom the footpath to get to “lower ground” in my complex?
Why was there one supra, one mitsu Evo X, one GTI, one skyline GTR, 2 HSV coupes a WRX STi, a civc type R (rally prepped) and 2 highly modified nissan patrols in my apartment carpark at midday? Why spend lots of money on a car then leave it parked in the garage all week long.
Why does the name “Craven Cottage” sound so cool?
Why did the butcher let me down? (Worst lamb shanks ever for diner tonight, I swear the sheep must have been 20 yr old reject stock).
Merlo or Di Bella?
Why does the microscope work fine when your cells don’t express the protein properly, but screws up when you get good clean expression?
Enough questions for now anyway…..
On another note, I’m going to cross post my ResearchGate Blog posts from their to hear aswell. Starting with this one on Gene therapy to restore color blindness.
A recent Nature letters paper by Mancuso et al details the use of a recombinant adeno-associated virus (rAAV) in gene delivery to restore the function of photo-pigments in squirrel monkeys. The male monkeys, red-green color-blind from birth, obtained the ability to process red-green color information via the delivery of the L-opsin gene into the retina.
While this research opens the door for further hope of gene therapy involved in human eye conditions, including blindness, it also raises some interesting questions. It was previously thought that the brain of adult monkeys would be too "hard-wired" to gain a beneficial effect from the restoration of deficient pathways. The recent paper proves that gene therapy can be utilized in "middle aged" monkeys, and is not solely an avenue to be pursued during early development. This adds a lot of significance to work already begun in human patients, to restore an enzyme involved in a type of hereditary blindness.
Original Article:
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08401.html
Gene therapy for red–green colour blindness in adult primates
Katherine Mancuso1, William W. Hauswirth2, Qiuhong Li2, Thomas B. Connor3, James A. Kuchenbecker1, Matthew C. Mauck3, Jay Neitz1 & Maureen Neitz1
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